Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Cyclin-dependent kinase 5 (CDK5) is a potential target for prostate cancer treatment, the enzyme being essential for prostate tumor growth and formation of metastases. In the present study, we identified agents that target prostate cancer cells based on CDK5 expression. CDK5 activity was suppressed...

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Detalles Bibliográficos
Autores principales: WISSING, MICHEL D., DADON, TIKVA, KIM, EUNICE, PIONTEK, KLAUS B., SHIM, JOONG S., KAELBER, NADINE S., LIU, JUN O., KACHHAP, SUSHANT K., NELKIN, BARRY D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067428/
https://www.ncbi.nlm.nih.gov/pubmed/24841903
http://dx.doi.org/10.3892/or.2014.3174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067428/
https://www.ncbi.nlm.nih.gov/pubmed/24841903
http://dx.doi.org/10.3892/or.2014.3174

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