The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation, and cell migration

Rac1-GTPases serve as intermediary cellular switches which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. While the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and has recently been linked to cancer cell motility as a...

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Detalles Bibliográficos
Autores principales: Saxena, Madhurima, Dykes, Samantha S., Malyarchuk, Svitlana, Wang, Allison E., Cardelli, James A., Pruitt, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067478/
https://www.ncbi.nlm.nih.gov/pubmed/24362520
http://dx.doi.org/10.1038/onc.2013.549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067478/
https://www.ncbi.nlm.nih.gov/pubmed/24362520
http://dx.doi.org/10.1038/onc.2013.549

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