Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Path...

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Detalles Bibliográficos
Autores principales: Knight, Thomas, Irving, Julie Anne Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067595/
https://www.ncbi.nlm.nih.gov/pubmed/25009801
http://dx.doi.org/10.3389/fonc.2014.00160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067595/
https://www.ncbi.nlm.nih.gov/pubmed/25009801
http://dx.doi.org/10.3389/fonc.2014.00160

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