Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

Huntington’s disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in Huntingtin(1). Mutant Huntingtin (mHTT) is ubiquitously expressed but elicits selective cortical and striatal neurodegeneration in HD...

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Detalles Bibliográficos
Autores principales: Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P., Holley, Sandra M., Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S., Yang, X. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067603/
https://www.ncbi.nlm.nih.gov/pubmed/24784230
http://dx.doi.org/10.1038/nm.3514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067603/
https://www.ncbi.nlm.nih.gov/pubmed/24784230
http://dx.doi.org/10.1038/nm.3514

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