Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling

Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of malate to yield CO(2) and pyruvate, with concomitant reduction of dinucleotide cofactor NAD(+) or NADP(+). We find that ME2 is highly expressed in many solid tumors. In the A549 non-small cell lung cancer (NSCLC) cell line...

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Detalles Bibliográficos
Autores principales: Ren, Jian-Guo, Seth, Pankaj, Clish, Clary B., Lorkiewicz, Pawel K., Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Sukhatme, Vikas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067620/
https://www.ncbi.nlm.nih.gov/pubmed/24957098
http://dx.doi.org/10.1038/srep05414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067620/
https://www.ncbi.nlm.nih.gov/pubmed/24957098
http://dx.doi.org/10.1038/srep05414

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