An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both nati...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Bo, Zarlenga, Dante S., Ren, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068083/
https://www.ncbi.nlm.nih.gov/pubmed/24995348
http://dx.doi.org/10.1155/2014/824630
_version_ 1782322382263812096
author Dong, Bo
Zarlenga, Dante S.
Ren, Xiaofeng
author_facet Dong, Bo
Zarlenga, Dante S.
Ren, Xiaofeng
author_sort Dong, Bo
collection PubMed
description Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.
format Online
Article
Text
id pubmed-4068083
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40680832014-07-03 An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines Dong, Bo Zarlenga, Dante S. Ren, Xiaofeng J Immunol Res Review Article Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals. Hindawi Publishing Corporation 2014 2014-06-05 /pmc/articles/PMC4068083/ /pubmed/24995348 http://dx.doi.org/10.1155/2014/824630 Text en Copyright © 2014 Bo Dong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dong, Bo
Zarlenga, Dante S.
Ren, Xiaofeng
An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title_full An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title_fullStr An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title_full_unstemmed An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title_short An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
title_sort overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068083/
https://www.ncbi.nlm.nih.gov/pubmed/24995348
http://dx.doi.org/10.1155/2014/824630
work_keys_str_mv AT dongbo anoverviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines
AT zarlengadantes anoverviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines
AT renxiaofeng anoverviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines
AT dongbo overviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines
AT zarlengadantes overviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines
AT renxiaofeng overviewofliveattenuatedrecombinantpseudorabiesvirusesforuseasnovelvaccines

Ejemplares similares