Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes

Intracellular protein degradation is primarily performed by the ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP). The interplay between these two pathways has been rarely examined in intact animals and the mechanism underlying the interplay remains unclear. Hence, we soug...

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Detalles Bibliográficos
Autores principales: Tian, Zongwen, Wang, Changhua, Hu, Chengjun, Tian, Yihao, Liu, Jinbao, Wang, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069113/
https://www.ncbi.nlm.nih.gov/pubmed/24959866
http://dx.doi.org/10.1371/journal.pone.0100715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069113/
https://www.ncbi.nlm.nih.gov/pubmed/24959866
http://dx.doi.org/10.1371/journal.pone.0100715

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