Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance

Evolution of resistance to drugs and pesticides poses a serious threat to human health and agricultural production. CYP51 encodes the target site of azole fungicides, widely used clinically and in agriculture. Azole resistance can evolve due to point mutations or overexpression of CYP51, and previou...

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Detalles Bibliográficos
Autores principales: Hawkins, Nichola J., Cools, Hans J., Sierotzki, Helge, Shaw, Michael W., Knogge, Wolfgang, Kelly, Steven L., Kelly, Diane E., Fraaije, Bart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069618/
https://www.ncbi.nlm.nih.gov/pubmed/24732957
http://dx.doi.org/10.1093/molbev/msu134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069618/
https://www.ncbi.nlm.nih.gov/pubmed/24732957
http://dx.doi.org/10.1093/molbev/msu134

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