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Structure guided homology model based design and engineering of mouse antibodies for humanization
No universal strategy exists for humanizing mouse antibodies, and most approaches are based on primary sequence alignment and grafting. Although this strategy theoretically decreases the immunogenicity of mouse antibodies, it neither addresses conformational changes nor steric clashes that arise due...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Biomedical Informatics
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070046/ https://www.ncbi.nlm.nih.gov/pubmed/24966517 http://dx.doi.org/10.6026/97320630010180 |