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Structure guided homology model based design and engineering of mouse antibodies for humanization

No universal strategy exists for humanizing mouse antibodies, and most approaches are based on primary sequence alignment and grafting. Although this strategy theoretically decreases the immunogenicity of mouse antibodies, it neither addresses conformational changes nor steric clashes that arise due...

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Detalles Bibliográficos
Autores principales: Kurella, Vinodh B, Gali, Reddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070046/
https://www.ncbi.nlm.nih.gov/pubmed/24966517
http://dx.doi.org/10.6026/97320630010180

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