Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats

We aimed to investigate the effect of induced hepatic and renal failure on the pharmacokinetics of topiramate (TPM) in rats. Twenty-four Sprague-Dawley rats were used in this study. Renal or hepatic failure was induced by a single i.p. dose of 7.5 mg/kg cisplatin (n = 8) or 0.5 mL/kg carbon tetrachl...

Descripción completa

Detalles Bibliográficos
Autores principales: Matar, Kamal M., Tayem, Yasin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070280/
https://www.ncbi.nlm.nih.gov/pubmed/25009818
http://dx.doi.org/10.1155/2014/570910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070280/
https://www.ncbi.nlm.nih.gov/pubmed/25009818
http://dx.doi.org/10.1155/2014/570910

Ejemplares similares