An alternate binding site for PPARγ ligands

PPARγ is a target for insulin sensitizing drugs such as glitazones, which improve plasma glucose maintenance in patients with diabetes. Synthetic ligands have been designed to mimic endogenous ligand binding to a canonical ligand-binding pocket to hyperactivate PPARγ. Here we reveal that synthetic P...

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Detalles Bibliográficos
Autores principales: Hughes, Travis S., Giri, Pankaj Kumar, de Vera, Ian Mitchelle S., Marciano, David P., Kuruvilla, Dana S., Shin, Youseung, Blayo, Anne-Laure, Kamenecka, Theodore M., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070320/
https://www.ncbi.nlm.nih.gov/pubmed/24705063
http://dx.doi.org/10.1038/ncomms4571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070320/
https://www.ncbi.nlm.nih.gov/pubmed/24705063
http://dx.doi.org/10.1038/ncomms4571

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