Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power. The production of radical species, specifically reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been proposed as an early unifying event linking the bioactivation of drugs to hepatotoxi...

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Detalles Bibliográficos
Autores principales: Shuhendler, Adam J., Pu, Kanyi, Cui, Lina, Uetrecht, Jack P., Rao, Jianghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070437/
https://www.ncbi.nlm.nih.gov/pubmed/24658645
http://dx.doi.org/10.1038/nbt.2838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070437/
https://www.ncbi.nlm.nih.gov/pubmed/24658645
http://dx.doi.org/10.1038/nbt.2838

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