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Dynamic imbalance between cancer cell subpopulations induced by Transforming Growth Factor Beta (TGF-β) is associated with a DNA methylome switch

BACKGROUND: Distinct subpopulations of neoplastic cells within tumors, including hepatocellular carcinoma (HCC), display pronounced ability to initiate new tumors and induce metastasis. Recent evidence suggests that signals from transforming growth factor beta (TGF-β) may increase the survival of th...

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Detalles Bibliográficos
Autores principales: Martin, Marion, Ancey, Pierre-Benoit, Cros, Marie-Pierre, Durand, Geoffroy, Le Calvez-Kelm, Florence, Hernandez-Vargas, Hector, Herceg, Zdenko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070873/
https://www.ncbi.nlm.nih.gov/pubmed/24898317
http://dx.doi.org/10.1186/1471-2164-15-435