Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist

Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The contribution of other classes of proteases to PAR activation has not been studied in...

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Detalles Bibliográficos
Autores principales: Elmariah, Sarina B., Reddy, Vemuri B., Lerner, Ethan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070910/
https://www.ncbi.nlm.nih.gov/pubmed/24964046
http://dx.doi.org/10.1371/journal.pone.0099702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070910/
https://www.ncbi.nlm.nih.gov/pubmed/24964046
http://dx.doi.org/10.1371/journal.pone.0099702

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