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Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The contribution of other classes of proteases to PAR activation has not been studied in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070910/ https://www.ncbi.nlm.nih.gov/pubmed/24964046 http://dx.doi.org/10.1371/journal.pone.0099702 |