Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

BACKGROUND: Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerge, circulating tumor cells (CTCs) from blood are being investigated for a role...

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Detalles Bibliográficos
Autores principales: Deng, Glenn, Krishnakumar, Sujatha, Powell, Ashley A, Zhang, Haiyu, Mindrinos, Michael N, Telli, Melinda L, Davis, Ronald W, Jeffrey, Stefanie S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071027/
https://www.ncbi.nlm.nih.gov/pubmed/24947048
http://dx.doi.org/10.1186/1471-2407-14-456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071027/
https://www.ncbi.nlm.nih.gov/pubmed/24947048
http://dx.doi.org/10.1186/1471-2407-14-456

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