BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex

BACKGROUND: BMP-induced chemotaxis of mesenchymal progenitors is fundamental for vertebrate development, disease and tissue repair. BMP2 induces Smad and non-Smad signalling. Whereas signal transduction via Smads lead to transcriptional responses, non-Smad signalling induces both, transcriptional an...

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Detalles Bibliográficos
Autores principales: Hiepen, Christian, Benn, Andreas, Denkis, Agnieszka, Lukonin, Ilya, Weise, Christoph, Boergermann, Jan H, Knaus, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071339/
https://www.ncbi.nlm.nih.gov/pubmed/24885555
http://dx.doi.org/10.1186/1741-7007-12-43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071339/
https://www.ncbi.nlm.nih.gov/pubmed/24885555
http://dx.doi.org/10.1186/1741-7007-12-43

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