Cargando…
Integrating Diverse Datasets Improves Developmental Enhancer Prediction
Gene-regulatory enhancers have been identified using various approaches, including evolutionary conservation, regulatory protein binding, chromatin modifications, and DNA sequence motifs. To integrate these different approaches, we developed EnhancerFinder, a two-step method for distinguishing devel...
Autores principales: | Erwin, Genevieve D., Oksenberg, Nir, Truty, Rebecca M., Kostka, Dennis, Murphy, Karl K., Ahituv, Nadav, Pollard, Katherine S., Capra, John A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072507/ https://www.ncbi.nlm.nih.gov/pubmed/24967590 http://dx.doi.org/10.1371/journal.pcbi.1003677 |
Ejemplares similares
-
Many human accelerated regions are developmental enhancers
por: Capra, John A., et al.
Publicado: (2013) -
Function and Regulation of AUTS2, a Gene Implicated in Autism and Human Evolution
por: Oksenberg, Nir, et al.
Publicado: (2013) -
A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design
por: Smith, Robin P, et al.
Publicado: (2013) -
Functionally conserved enhancers with divergent sequences in distant vertebrates
por: Yang, Song, et al.
Publicado: (2015) -
Developmental Loci Harbor Clusters of Accelerated Regions That Evolved Independently in Ape Lineages
por: Kostka, Dennis, et al.
Publicado: (2018)