ATRA-Induced Cellular Differentiation and CD38 Expression Inhibits Acquisition of BCR-ABL Mutations for CML Acquired Resistance

Acquired resistance through genetic mutations is a major obstacle in targeted cancer therapy, but the underlying mechanisms are poorly understood. Here we studied mechanisms of acquired resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) by examining genome-wide gene ex...

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Detalles Bibliográficos
Autores principales: Wang, Zhiqiang, Liu, Zheng, Wu, Xiwei, Chu, Su, Wang, Jinhui, Yuan, Hongfeng, Roth, Mendel, Yuan, Yate-Ching, Bhatia, Ravi, Chen, WenYong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072521/
https://www.ncbi.nlm.nih.gov/pubmed/24967705
http://dx.doi.org/10.1371/journal.pgen.1004414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072521/
https://www.ncbi.nlm.nih.gov/pubmed/24967705
http://dx.doi.org/10.1371/journal.pgen.1004414

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