MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly

The regulation of Rho-family GTPases is crucial to direct the formation of cell–cell junctions and tissue barriers. Cingulin (CGN) and paracingulin (CGNL1) control RhoA activation in epithelial cells by interacting with RhoA guanidine exchange factors. CGNL1 depletion also inhibits Rac1 activation d...

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Detalles Bibliográficos
Autores principales: Guillemot, Laurent, Guerrera, Diego, Spadaro, Domenica, Tapia, Rocio, Jond, Lionel, Citi, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072573/
https://www.ncbi.nlm.nih.gov/pubmed/24807907
http://dx.doi.org/10.1091/mbc.E13-11-0680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072573/
https://www.ncbi.nlm.nih.gov/pubmed/24807907
http://dx.doi.org/10.1091/mbc.E13-11-0680

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