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Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene
The mammalian Shc family, composed of p46, p52, and p66 isoforms, serves as an adaptor protein in cell growth and stress response. p66Shc was shown to be a negative lifespan regulator by acting as a prooxidant protein in mitochondria; however, the regulatory mechanisms of p66Shc expression and funct...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072584/ https://www.ncbi.nlm.nih.gov/pubmed/24807908 http://dx.doi.org/10.1091/mbc.E13-11-0666 |