A Nucleic-Acid Hydrolyzing Single Chain Antibody Confers Resistance to DNA Virus Infection in HeLa Cells and C57BL/6 Mice

Viral protein neutralizing antibodies have been developed but they are limited only to the targeted virus and are often susceptible to antigenic drift. Here, we present an alternative strategy for creating virus-resistant cells and animals by ectopic expression of a nucleic acid hydrolyzing catalyti...

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Detalles Bibliográficos
Autores principales: Lee, Gunsup, Yu, Jaelim, Cho, Seungchan, Byun, Sung-June, Kim, Dae Hyun, Lee, Taek-Kyun, Kwon, Myung-Hee, Lee, Sukchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072776/
https://www.ncbi.nlm.nih.gov/pubmed/24968358
http://dx.doi.org/10.1371/journal.ppat.1004208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072776/
https://www.ncbi.nlm.nih.gov/pubmed/24968358
http://dx.doi.org/10.1371/journal.ppat.1004208

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