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Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Persistent infections are subject to constant surveillance by CD8(+) cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However t...

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Detalles Bibliográficos
Autores principales: Godinho-Silva, Cristina, Marques, Sofia, Fontinha, Diana, Veiga-Fernandes, Henrique, Stevenson, Philip G., Simas, J. Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072806/
https://www.ncbi.nlm.nih.gov/pubmed/24967892
http://dx.doi.org/10.1371/journal.ppat.1004220