Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas. Overexpression of bach1b or knockdown of nrf2a...

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Detalles Bibliográficos
Autores principales: Zhang, Shuqing, Xu, Minrui, Huang, Jian, Tang, Lili, Zhang, Yanqing, Wu, Jingyao, Lin, Shuo, Wang, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073273/
https://www.ncbi.nlm.nih.gov/pubmed/24652768
http://dx.doi.org/10.1242/dmm.014951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073273/
https://www.ncbi.nlm.nih.gov/pubmed/24652768
http://dx.doi.org/10.1242/dmm.014951

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