Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

Abnormalities and impairments in axonal transport are suggested to strongly contribute to the pathological alterations underlying AD. The exact mechanisms leading to axonopathy are currently unclear, but it was recently suggested that APP expression itself triggers axonal degeneration. We used APP t...

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Detalles Bibliográficos
Autores principales: Christensen, Ditte Z., Huettenrauch, Melanie, Mitkovski, Miso, Pradier, Laurent, Wirths, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073286/
https://www.ncbi.nlm.nih.gov/pubmed/25018730
http://dx.doi.org/10.3389/fnagi.2014.00139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073286/
https://www.ncbi.nlm.nih.gov/pubmed/25018730
http://dx.doi.org/10.3389/fnagi.2014.00139

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