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Epimorphin Alters the Inhibitory Effects of SOX9 on Mmp13 in Activated Hepatic Stellate Cells

BACKGROUND AND AIMS: Liver fibrosis is a major cause of morbidity and mortality. It is characterised by excessive extracellular matrix (ECM) deposition from activated hepatic stellate cells (HSCs). Although potentially reversible, treatment remains limited. Understanding how ECM influences the patho...

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Detalles Bibliográficos
Autores principales: Pritchett, James, Athwal, Varinder S., Harvey, Emma, Martin, Katherine, Llewellyn, Jessica, Ireland, Philip, Nicolaides, Alexander, Humphries, Martin J., Bobola, Nicoletta, Hanley, Neil A., Piper Hanley, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074045/
https://www.ncbi.nlm.nih.gov/pubmed/24971829
http://dx.doi.org/10.1371/journal.pone.0100091