Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing

Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug ‘resistance’, underpinning a drive for new antiplatelet agents. To discover such drugs, one strategy i...

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Detalles Bibliográficos
Autores principales: Taylor, Lewis, Vasudevan, Sridhar R., Jones, Chris I., Gibbins, Jonathan M., Churchill, Grant C., Campbell, R. Duncan, Coxon, Carmen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074120/
https://www.ncbi.nlm.nih.gov/pubmed/24971515
http://dx.doi.org/10.1371/journal.pone.0101209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074120/
https://www.ncbi.nlm.nih.gov/pubmed/24971515
http://dx.doi.org/10.1371/journal.pone.0101209

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