A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

The homologous recombination pathway is responsible for the repair of DNA double strand breaks. RAD51, a key homologous recombination protein, promotes the search for homology and DNA strand exchange between homologous DNA molecules. RAD51 is overexpressed in a variety of cancer cells. Downregulatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Fei, Mazin, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074124/
https://www.ncbi.nlm.nih.gov/pubmed/24971740
http://dx.doi.org/10.1371/journal.pone.0100993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074124/
https://www.ncbi.nlm.nih.gov/pubmed/24971740
http://dx.doi.org/10.1371/journal.pone.0100993

Ejemplares similares