Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E(2) Synthase-1
[Image: see text] The microsomal prostaglandin E(2) synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E(2) from cyclooxygenase (COX)-derived PGH(2). We previously found that mPGES-1 is inhibited by boswellic acids (IC(50) = 3–30 μM), which are bioactive triterpene ac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074212/ https://www.ncbi.nlm.nih.gov/pubmed/24844534 http://dx.doi.org/10.1021/np500198g |