Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E(2) Synthase-1

[Image: see text] The microsomal prostaglandin E(2) synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E(2) from cyclooxygenase (COX)-derived PGH(2). We previously found that mPGES-1 is inhibited by boswellic acids (IC(50) = 3–30 μM), which are bioactive triterpene ac...

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Detalles Bibliográficos
Autores principales: Verhoff, Moritz, Seitz, Stefanie, Paul, Michael, Noha, Stefan M., Jauch, Johann, Schuster, Daniela, Werz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074212/
https://www.ncbi.nlm.nih.gov/pubmed/24844534
http://dx.doi.org/10.1021/np500198g

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