Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets

BACKGROUND: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate target gene dosage with cellular phenotypes. This however requires a set of RNAi...

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Detalles Bibliográficos
Autores principales: Micklem, David R, Blø, Magnus, Bergström, Petra, Hodneland, Erlend, Tiron, Crina, Høiby, Torill, Gjerdrum, Christine, Hammarsten, Ola, Lorens, James B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074332/
https://www.ncbi.nlm.nih.gov/pubmed/24952598
http://dx.doi.org/10.1186/1472-6750-14-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074332/
https://www.ncbi.nlm.nih.gov/pubmed/24952598
http://dx.doi.org/10.1186/1472-6750-14-57

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