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Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets

BACKGROUND: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate target gene dosage with cellular phenotypes. This however requires a set of RNAi...

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Detalles Bibliográficos
Autores principales:	Micklem, David R, Blø, Magnus, Bergström, Petra, Hodneland, Erlend, Tiron, Crina, Høiby, Torill, Gjerdrum, Christine, Hammarsten, Ola, Lorens, James B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074332/ https://www.ncbi.nlm.nih.gov/pubmed/24952598 http://dx.doi.org/10.1186/1472-6750-14-57

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