Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS

BACKGROUND: Parkinson’s disease (PD) is a movement neurodegenerative disorder characterized by death of dopaminergic neurons in the substantia nigra pars compacta of the brain that leads to movement impairments including bradykinesia, resting tremor, postural instability and rigidity. Mutations in s...

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Detalles Bibliográficos
Autores principales: Bendikov-Bar, Inna, Rapaport, Debora, Larisch, Sarit, Horowitz, Mia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074407/
https://www.ncbi.nlm.nih.gov/pubmed/24935484
http://dx.doi.org/10.1186/1750-1172-9-86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074407/
https://www.ncbi.nlm.nih.gov/pubmed/24935484
http://dx.doi.org/10.1186/1750-1172-9-86

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