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STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

The transcription factor STAT3 regulates genes that control critical cellular processes such as proliferation, survival, pluripotency, and motility. Thus, under physiological conditions, the transcriptional function of STAT3 is tightly regulated as one part of a complex signaling matrix. When these...

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Detalles Bibliográficos
Autores principales: Walker, Sarah R., Xiang, Michael, Frank, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074811/
https://www.ncbi.nlm.nih.gov/pubmed/24762632
http://dx.doi.org/10.3390/cancers6020958
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author Walker, Sarah R.
Xiang, Michael
Frank, David A.
author_facet Walker, Sarah R.
Xiang, Michael
Frank, David A.
author_sort Walker, Sarah R.
collection PubMed
description The transcription factor STAT3 regulates genes that control critical cellular processes such as proliferation, survival, pluripotency, and motility. Thus, under physiological conditions, the transcriptional function of STAT3 is tightly regulated as one part of a complex signaling matrix. When these processes are subverted through mutation or epigenetic events, STAT3 becomes highly active and drives elevated expression of genes underlying these phenotypes, leading to malignant cellular behavior. However, even in the presence of activated STAT3, other cellular modulators can have a major impact on the biological properties of a cancer cell, which is reflected in the clinical behavior of a tumor. Recent evidence has suggested that two such key modulators are the activation status of other STAT family members, particularly STAT5, and the expression of STAT3-regulated genes that are part of negative feedback circuits, including microRNAs such as miR-146b. With attention to these newly emerging areas, we will gain greater insight into the consequence of STAT3 activation in the biology of human cancers. In addition, understanding these subtleties of STAT3 signaling in cancer pathogenesis will allow the development of more rational molecular approaches to cancer therapy.
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spelling pubmed-40748112014-06-30 STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b Walker, Sarah R. Xiang, Michael Frank, David A. Cancers (Basel) Review The transcription factor STAT3 regulates genes that control critical cellular processes such as proliferation, survival, pluripotency, and motility. Thus, under physiological conditions, the transcriptional function of STAT3 is tightly regulated as one part of a complex signaling matrix. When these processes are subverted through mutation or epigenetic events, STAT3 becomes highly active and drives elevated expression of genes underlying these phenotypes, leading to malignant cellular behavior. However, even in the presence of activated STAT3, other cellular modulators can have a major impact on the biological properties of a cancer cell, which is reflected in the clinical behavior of a tumor. Recent evidence has suggested that two such key modulators are the activation status of other STAT family members, particularly STAT5, and the expression of STAT3-regulated genes that are part of negative feedback circuits, including microRNAs such as miR-146b. With attention to these newly emerging areas, we will gain greater insight into the consequence of STAT3 activation in the biology of human cancers. In addition, understanding these subtleties of STAT3 signaling in cancer pathogenesis will allow the development of more rational molecular approaches to cancer therapy. MDPI 2014-04-23 /pmc/articles/PMC4074811/ /pubmed/24762632 http://dx.doi.org/10.3390/cancers6020958 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Walker, Sarah R.
Xiang, Michael
Frank, David A.
STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title_full STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title_fullStr STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title_full_unstemmed STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title_short STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
title_sort stat3 activity and function in cancer: modulation by stat5 and mir-146b
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074811/
https://www.ncbi.nlm.nih.gov/pubmed/24762632
http://dx.doi.org/10.3390/cancers6020958
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