An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein

Extracellular Hsp90 (eHsp90) activates a number of client proteins outside of cancer cells required for migration and invasion. Therefore, eHsp90 may serve as a novel target for anti-metastatic drugs as its inhibition using impermeant Hsp90 inhibitors would not affect the numerous vital intracellula...

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Detalles Bibliográficos
Autores principales: McCready, Jessica, Wong, Daniel S., Burlison, Joseph A., Ying, Weiwen, Jay, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074815/
https://www.ncbi.nlm.nih.gov/pubmed/24785146
http://dx.doi.org/10.3390/cancers6021031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074815/
https://www.ncbi.nlm.nih.gov/pubmed/24785146
http://dx.doi.org/10.3390/cancers6021031

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