The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease

BACKGROUND: The Src homology-2 domain protein B (Shb) is an adapter protein operating downstream of several tyrosine kinase receptors and consequently Shb regulates various cellular responses. Absence of Shb was recently shown to reduce hematopoietic stem cell proliferation through activation of foc...

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Detalles Bibliográficos
Autores principales: Gustafsson, Karin, Jamalpour, Maria, Trinh, Camilla, Kharas, Michael G, Welsh, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074852/
https://www.ncbi.nlm.nih.gov/pubmed/24952416
http://dx.doi.org/10.1186/1756-8722-7-45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074852/
https://www.ncbi.nlm.nih.gov/pubmed/24952416
http://dx.doi.org/10.1186/1756-8722-7-45

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