Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1. In this study, we show that SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to...

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Detalles Bibliográficos
Autores principales: Bonasio, Roberto, Lecona, Emilio, Narendra, Varun, Voigt, Philipp, Parisi, Fabio, Kluger, Yuval, Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074974/
https://www.ncbi.nlm.nih.gov/pubmed/24986859
http://dx.doi.org/10.7554/eLife.02637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074974/
https://www.ncbi.nlm.nih.gov/pubmed/24986859
http://dx.doi.org/10.7554/eLife.02637

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