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Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo

The compounds 6-dimethylaminopurine and cycloheximide promote the successful production of cloned mammals and have been used in the development of embryos produced by somatic cell nuclear transfer. This study investigated the effects of 6-dimethylaminopurine and cycloheximide in vitro, using the thi...

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Detalles Bibliográficos
Autores principales: Oliveira, R.J., Mantovani, M.S., da Silva, A.F., Pesarini, J.R., Mauro, M.O., Ribeiro, L.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075292/
https://www.ncbi.nlm.nih.gov/pubmed/24714812
http://dx.doi.org/10.1590/1414-431X20143301