Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia

Defects in SLX4, a scaffold for DNA repair nucleases, result in Fanconi anemia (FA), due to the defective repair of inter-strand DNA crosslinks (ICLs). Some FA patients have an SLX4 deletion removing two tandem UBZ4-type ubiquitin-binding domains that are implicated in protein recruitment to sites o...

Descripción completa

Detalles Bibliográficos
Autores principales: Lachaud, Christophe, Castor, Dennis, Hain, Karolina, Muñoz, Ivan, Wilson, Jamie, MacArtney, Thomas J., Schindler, Detlev, Rouse, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075355/
https://www.ncbi.nlm.nih.gov/pubmed/24794496
http://dx.doi.org/10.1242/jcs.146167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075355/
https://www.ncbi.nlm.nih.gov/pubmed/24794496
http://dx.doi.org/10.1242/jcs.146167

Ejemplares similares