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A recombinant RNA bacteriophage system to identify functionally important nucleotides in a self-cleaving ribozyme
BACKGROUND: RNA bacteriophages like Qbeta and MS2 are well known for their high mutation rate, short infection cycle and strong selection against foreign inserts. The hammerhead ribozyme (HHRz) is a small self-cleaving RNA molecule whose active residues have previously been identified by mutational...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075628/ https://www.ncbi.nlm.nih.gov/pubmed/24946926 http://dx.doi.org/10.1186/1743-422X-11-116 |