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A Chemical Strategy for the Cell-Based Detection of HDAC Activity
[Image: see text] A strategy for activity-based enzyme detection using a novel enamide-based chemical strategy is described. Enzymatic cleavage of an amide bond results in the formation of an aldehyde. The interaction of this aldehyde with proteins increases retention in cells that express the enzym...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076023/ https://www.ncbi.nlm.nih.gov/pubmed/25056147 http://dx.doi.org/10.1021/cb500248r |