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Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol
[Image: see text] Herein, we report the first synthesis of a demethylated form of cholesterol (18,19-di-nor-cholesterol), in which the C18 and C19 methyl groups of the β-face were eliminated. Recent molecular simulations modeling 18,19-di-nor-cholesterol have suggested that cholesterol’s opposing ro...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076041/ https://www.ncbi.nlm.nih.gov/pubmed/24823889 http://dx.doi.org/10.1021/jo500813n |