Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway

BACKGROUND: Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is reported to exert anti-tumor effects by upregulating the expression of the natural killer group 2D (NKG2D) ligands on tumor cells; however, the mechanisms vary in different tumor types, and the effect and mechanism of action...

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Detalles Bibliográficos
Autores principales: Shi, Pengfei, Yin, Tao, Zhou, Feng, Cui, Pengfei, Gou, Shanmiao, Wang, Chunyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076062/
https://www.ncbi.nlm.nih.gov/pubmed/24885711
http://dx.doi.org/10.1186/1471-2407-14-370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076062/
https://www.ncbi.nlm.nih.gov/pubmed/24885711
http://dx.doi.org/10.1186/1471-2407-14-370

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