Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and GSK2141795 are orally bioavailable, potent inhibitors of the AKT kinases that have progressed to human clinical studies. Both compounds are selectiv...

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Detalles Bibliográficos
Autores principales: Dumble, Melissa, Crouthamel, Ming-Chih, Zhang, Shu-Yun, Schaber, Michael, Levy, Dana, Robell, Kimberly, Liu, Qi, Figueroa, David J., Minthorn, Elisabeth A., Seefeld, Mark A., Rouse, Meagan B., Rabindran, Sridhar K., Heerding, Dirk A., Kumar, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076210/
https://www.ncbi.nlm.nih.gov/pubmed/24978597
http://dx.doi.org/10.1371/journal.pone.0100880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076210/
https://www.ncbi.nlm.nih.gov/pubmed/24978597
http://dx.doi.org/10.1371/journal.pone.0100880

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