Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and GSK2141795 are orally bioavailable, potent inhibitors of the AKT kinases that have progressed to human clinical studies. Both compounds are selectiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumble, Melissa, Crouthamel, Ming-Chih, Zhang, Shu-Yun, Schaber, Michael, Levy, Dana, Robell, Kimberly, Liu, Qi, Figueroa, David J., Minthorn, Elisabeth A., Seefeld, Mark A., Rouse, Meagan B., Rabindran, Sridhar K., Heerding, Dirk A., Kumar, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076210/
https://www.ncbi.nlm.nih.gov/pubmed/24978597
http://dx.doi.org/10.1371/journal.pone.0100880

Ejemplares similares

Ejemplares similares