Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Iron-dependent halogenases employ cis-halo-Fe(IV)-oxo (haloferryl) complexes to functionalize unactivated aliphatic carbon centers, a capability elusive to synthetic chemists. Halogenation requires (1) coordination of a halide anion (Cl(−) or Br(−)) to the enzyme's Fe(II) cofactor; (2) coupled...

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Detalles Bibliográficos
Autores principales: Matthews, Megan L, Chang, Wei-chen, Layne, Andrew P, Miles, Linde A, Krebs, Carsten, Bollinger, J Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076429/
https://www.ncbi.nlm.nih.gov/pubmed/24463698
http://dx.doi.org/10.1038/nchembio.1438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076429/
https://www.ncbi.nlm.nih.gov/pubmed/24463698
http://dx.doi.org/10.1038/nchembio.1438

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