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Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin

P2X4 receptors are adenosine triphosphate (ATP)-gated cation channels present on the plasma membrane (PM) and also within intracellular compartments such as vesicles, vacuoles, lamellar bodies (LBs), and lysosomes. P2X4 receptors in microglia are up-regulated in epilepsy and in neuropathic pain; tha...

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Detalles Bibliográficos
Autores principales: Xu, Ji, Chai, Hua, Ehinger, Konstantin, Egan, Terrance M., Srinivasan, Rahul, Frick, Manfred, Khakh, Baljit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076521/
https://www.ncbi.nlm.nih.gov/pubmed/24935743
http://dx.doi.org/10.1085/jgp.201411169