Exposure–Response Modeling of Clinical End Points Using Latent Variable Indirect Response Models

Exposure–response modeling facilitates effective dosing regimen selection in clinical drug development, where the end points are often disease scores and not physiological variables. Appropriate models need to be consistent with pharmacology and identifiable from the time courses of available data....

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Detalles Bibliográficos
Autor principal: Hu, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076802/
https://www.ncbi.nlm.nih.gov/pubmed/24897307
http://dx.doi.org/10.1038/psp.2014.15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076802/
https://www.ncbi.nlm.nih.gov/pubmed/24897307
http://dx.doi.org/10.1038/psp.2014.15

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