Effects of IL-1β–Blocking Therapies in Type 2 Diabetes Mellitus: A Quantitative Systems Pharmacology Modeling Approach to Explore Underlying Mechanisms

Recent clinical studies suggest sustained treatment effects of interleukin-1β (IL-1β)–blocking therapies in type 2 diabetes mellitus. The underlying mechanisms of these effects, however, remain underexplored. Using a quantitative systems pharmacology modeling approach, we combined ex vivo data of IL...

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Detalles Bibliográficos
Autores principales: Palmér, R, Nyman, E, Penney, M, Marley, A, Cedersund, G, Agoram, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076803/
https://www.ncbi.nlm.nih.gov/pubmed/24918743
http://dx.doi.org/10.1038/psp.2014.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076803/
https://www.ncbi.nlm.nih.gov/pubmed/24918743
http://dx.doi.org/10.1038/psp.2014.16

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